The complete list:
Introducing the option that will provide the champion lots of healing in lane plus saving and enhancing early game. A detailed description of everything that is contained in it will allow you to fully understand its strengths and weaknesses.
|Position||What to choose|
|Additional||Triumph, Legend: Alacrity, Coup de Grace|
|Slots in it||Bone Plating, Overgrowth|
|Stats||10% attack speed, 9 adaptive force, 6 armor|
The main path for the champion Vayne is Precision. In it, you will need to choose one keystone rune, as well as three additional ones with less influence.
Fleet Footwork is used as the keystone rune. With its help Vayne will provide himself with the restoration of health on the lane. This rune is protective, since it does not increase damage to the enemy, but it does not allow enemy to easily lower your health, drive you out of the lane or kill.
Triumph is a very powerful rune, giving healing and additional gold when participating in the killing of an enemy champion. Legend: Alacrity will provide a decent amount of attack speed. Coup de Grace will allow you to do more damage to enemies with low health.
The secondary path is Resolve. Here you need to choose two additional runes for Vayne.
Bone Plating will reduce the incoming damage of the first enemy attacks and skills, which will make you less vulnerable to skirmishes and initiations. Overgrowth gives a gradual accumulation of health, and after a certain value you will receive a percentage bonus to HP.