The complete list:

Runes for Vayne in League of Legends S10 (2020)

We present you the best options with all the suitable keystones for season 10. The runes listed below showed effectiveness for this character in 2020, because they can unleash most of strengths, while neutralizing the maximum amount of weaknesses.

If possible, the list includes as many different options and their variations as possible to help you better adapt to your lane opponent and team composition when playing the champion Vayne (for example, if you need maximum aggression).

Please, choose the position you need

Bot lane

Top lane


Vayne runes for ADC in League of Legends

All the optimal builds for bot lane in LoL


Vayne runes for top in League of Legends

All the optimal builds for top lane in LoL