The complete list:

Bot lane (view best option)

Top lane (view best option)

ARAM 5v5 (view best option)

Runes for Vayne in League of Legends season 10

We present you all the best options available in S10. The runes listed below on the page showed effectiveness for this character in 2020 year, because they can unlock most of his strengths and also neutralize the maximum possible amount of weaknesses.

The list includes all the options that have any value nowadays. This will allow to flexibly adapt to your opponent in the role and team compositions in general when playing the champion Vayne (for example, if you need to be really aggressive).

Please, choose the position you need

Bot lane

Top lane

ARAM 5v5


Vayne runes for adc in League of Legends

All the optimal builds for bot lane in LoL

Vayne runes: adc №1 in LoL S10

More damage for aggression

Plus maximum increase in strength

Primary path

Precision

Press the Attack

Triumph

Secondary

Sorcery

Nimbus Cloak

Gathering Storm

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Sorcery. Nimbus Cloak will give the champion a good movement speed boost after using a summoner spell. Gathering Storm will allow... read more

Vayne runes: adc №2 in LoL S10

More damage for aggression

Plus restoration of health in the fight

Primary path

Precision

Press the Attack

Triumph

Secondary

Domination

Taste of Blood

Ravenous Hunter

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Vayne runes: adc №3 in LoL S10

More damage for aggression

Plus saving and enhancing early game

Primary path

Precision

Press the Attack

Triumph

Secondary

Inspiration

Magical Footwear

Biscuit Delivery

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Biscuit Delivery will provide... read more

Vayne runes: adc №4 in LoL S10

More damage for aggression

Plus increasing champion survivability

Primary path

Precision

Press the Attack

Triumph

Secondary

Resolve

Bone Plating

Overgrowth

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Resolve. Bone Plating will reduce the incoming damage of the first enemy attacks and skills, which will make you less vulnerable... read more

Vayne runes: adc №5 in LoL S10

Powerful auto attacks series

Plus fighting power and attack speed

Primary path

Domination

Hail of Blades

Taste of Blood

Secondary

Precision

Triumph

Legend: Alacrity

+ 2 others and statistics slots

Read complete description

Hail of Blades together with all the additional runes from Domination path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Precision. Triumph is very powerful, giving healing and additional gold when participating in the killing of an enemy champion... read more

Vayne runes: adc №6 in LoL S10

Lots of healing for champion

Plus saving and enhancing early game

Primary path

Precision

Fleet Footwork

Triumph

Secondary

Inspiration

Magical Footwear

Biscuit Delivery

+ 2 others and statistics slots

Read complete description

Fleet Footwork together with all the additional runes from Precision path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Biscuit Delivery will provide... read more

Vayne runes: adc №7 in LoL S10

Lots of healing for champion

Plus maximum increase in strength

Primary path

Precision

Fleet Footwork

Triumph

Secondary

Sorcery

Nimbus Cloak

Gathering Storm

+ 2 others and statistics slots

Read complete description

Fleet Footwork together with all the additional runes from Precision path will make Vayne much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Sorcery. Nimbus Cloak will give the champion a good movement speed boost after using a summoner spell. Gathering Storm will allow... read more


Vayne runes for top in League of Legends

All the optimal builds for top lane in LoL

Vayne runes: top №1 in LoL S10

More damage for aggression

Plus restoration of health in the fight

Primary path

Precision

Press the Attack

Triumph

Secondary

Domination

Taste of Blood

Ravenous Hunter

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Vayne runes: top №2 in LoL S10

More damage for aggression

Plus saving and enhancing early game

Primary path

Precision

Press the Attack

Triumph

Secondary

Inspiration

Magical Footwear

Biscuit Delivery

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Biscuit Delivery will provide... read more

Vayne runes: top №3 in LoL S10

More damage for aggression

Plus maximum increase in strength

Primary path

Precision

Press the Attack

Triumph

Secondary

Sorcery

Nimbus Cloak

Gathering Storm

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Sorcery. Nimbus Cloak will give the champion a good movement speed boost after using a summoner spell. Gathering Storm will allow... read more

Vayne runes: top №4 in LoL S10

More damage for aggression

Plus increasing champion survivability

Primary path

Precision

Press the Attack

Triumph

Secondary

Resolve

Bone Plating

Overgrowth

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Resolve. Bone Plating will reduce the incoming damage of the first enemy attacks and skills, which will make you less vulnerable... read more

Vayne runes: top №5 in LoL S10

Powerful auto attacks series

Plus fighting power and attack speed

Primary path

Domination

Hail of Blades

Taste of Blood

Secondary

Precision

Triumph

Legend: Alacrity

+ 2 others and statistics slots

Read complete description

Hail of Blades together with all the additional runes from Domination path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Precision. Triumph is very powerful, giving healing and additional gold when participating in the killing of an enemy champion... read more

Vayne runes: top №6 in LoL S10

Healing and scaling tankiness

Plus fighting power and attack speed

Primary path

Resolve

Grasp of the Undying

Demolish

Secondary

Precision

Triumph

Legend: Alacrity

+ 2 others and statistics slots

Read complete description

Grasp of the Undying together with all the additional runes from Resolve path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Precision. Triumph is very powerful, giving healing and additional gold when participating in the killing of an enemy champion... read more

Vayne runes: top №7 in LoL S10

Lots of healing for champion

Plus restoration of health in the fight

Primary path

Precision

Fleet Footwork

Triumph

Secondary

Domination

Taste of Blood

Ravenous Hunter

+ 2 others and statistics slots

Read complete description

Fleet Footwork together with all the additional runes from Precision path will make Vayne much stronger while playing top lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more


Vayne runes for ARAM in League of Legends

All the optimal builds for the ARAM in LoL

Vayne runes: ARAM №1 in LoL S10

More damage for aggression

Plus restoration of health in the fight

Primary path

Precision

Press the Attack

Triumph

Secondary

Domination

Taste of Blood

Ravenous Hunter

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Vayne runes: ARAM №2 in LoL S10

More damage for aggression

Plus maximum increase in strength

Primary path

Precision

Press the Attack

Triumph

Secondary

Sorcery

Nimbus Cloak

Gathering Storm

+ 2 others and statistics slots

Read complete description

Press the Attack together with all the additional runes from Precision path will make Vayne much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Sorcery. Nimbus Cloak will give the champion a good movement speed boost after using a summoner spell. Gathering Storm will allow... read more

Vayne runes: ARAM №3 in LoL S10

Increasing the attack speed

Plus restoration of health in the fight

Primary path

Precision

Lethal Tempo

Triumph

Secondary

Domination

Taste of Blood

Ravenous Hunter

+ 2 others and statistics slots

Read complete description

Lethal Tempo together with all the additional runes from Precision path will make Vayne much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Vayne runes: ARAM №4 in LoL S10

Powerful auto attacks series

Plus fighting power and attack speed

Primary path

Domination

Hail of Blades

Taste of Blood

Secondary

Precision

Triumph

Legend: Alacrity

+ 2 others and statistics slots

Read complete description

Hail of Blades together with all the additional runes from Domination path will make Vayne much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Precision. Triumph is very powerful, giving healing and additional gold when participating in the killing of an enemy champion... read more