The complete list:
In jungle (view best option)
Mid lane (view best option)
Bot lane (view best option)
In ARAM (view best option)
Introducing the runes that will provide the champion harassing enemy with skills plus significant CDR of the ultimate. A detailed description of everything that is contained in it will allow you to fully understand its strengths and weaknesses.
Below on this page you will see what you need to take – the main branch, additional, and slots with stats. Also you can find out the advantages of the option. Keep in mind that it may not always be ideal for your situation depending on team compositions.
You can get detailed information about all runes, as well as find out any of their numerical values, at the stage of setting them up in the League of Legends client using the option in the lower left corner.
Keep in mind that this is just one of the options, so we recommend you to check them all. Depending on the situation, their priority may change, for example, due to the composition of the teams or the opponent in your role.
Phase Rush is used as the keystone. With its help Karthus significantly increase its mobility. Hit the enemy with skills and basic attacks three times, and the rune will give you a gigantic bonus to the movement speed, which will allow you to catch up with the retreating enemy or to avoid death.
Nimbus Cloak will give the champion a good movement speed boost after using a summoner spell. Absolute Focus will maximize the advantage over the opponent thanks to additional stats when your level of health is high. Gathering Storm will allow you to take up the enemy in long games thanks to a large amount of attack damage or ability power.
Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as permanently increase its amount. Coup de Grace will allow you to do more damage to enemies with low health.
When playing in the jungle, you need to use armor as a defensive stat. This is due to the fact that monsters do almost exclusively physical damage, which means that armor will help you lose less health in battle against them.