The complete list:

In jungle (view best option)

Mid lane (view best option)

Bot lane (view best option)

In ARAM (view best option)

Runes for Karthus in League of Legends season 10

We present you all the best options available in S10. The runes listed below on the page showed effectiveness for this character in 2020 year, because they can unlock most of his strengths and also neutralize the maximum possible amount of weaknesses.

The list includes all the options that have any value nowadays. This will allow to flexibly adapt to your opponent in the role and team compositions in general when playing the champion Karthus (for example, if you need to be really aggressive).

Please, choose the position you need

In jungle

Mid lane

Bot lane

In ARAM


Karthus runes for jng in League of Legends

All the optimal builds for the jungle in LoL

Karthus runes: jng №1 in LoL S10

Continuous damage increase

Plus more mana and threat to enemies

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing the jungle in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Karthus runes: jng №2 in LoL S10

Continuous damage increase

Plus saving in the early game and CDR

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Inspiration
  7. Magical Footwear
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing the jungle in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Cosmic Insight allows you to get... read more

Karthus runes: jng №3 in LoL S10

Continuous damage increase

Plus maximum increase in strength

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Sorcery
  7. Absolute Focus
  8. Gathering Storm
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing the jungle in season 10 League of Legends.

The secondary path is Sorcery. Absolute Focus will maximize the advantage over the opponent thanks to additional stats when your level of health is... read more

Karthus runes: jng №4 in LoL S10

Damage and lots of healing

Plus maximum increase in strength

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  1. Precision
  2. Conqueror
  3. Triumph
  4. Legend: Tenacity
  5. Coup de Grace
  6. Sorcery
  7. Absolute Focus
  8. Gathering Storm
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Conqueror together with all the additional runes from Precision path will make Karthus much stronger while playing the jungle in season 10 League of Legends.

The secondary path is Sorcery. Absolute Focus will maximize the advantage over the opponent thanks to additional stats when your level of health is... read more

Karthus runes: jng №5 in LoL S10

Damage and lots of healing

Plus saving in the early game and CDR

Read complete description

  1. Precision
  2. Conqueror
  3. Triumph
  4. Legend: Tenacity
  5. Coup de Grace
  6. Inspiration
  7. Magical Footwear
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Conqueror together with all the additional runes from Precision path will make Karthus much stronger while playing the jungle in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Cosmic Insight allows you to get... read more

Karthus runes: jng №6 in LoL S10

Impressive amount of mobility

Plus more mana and threat to enemies

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  1. Sorcery
  2. Phase Rush
  3. Nimbus Cloak
  4. Absolute Focus
  5. Gathering Storm
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Karthus much stronger while playing the jungle in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more


Karthus runes for mid in League of Legends

All the optimal builds for mid lane in LoL

Karthus runes: mid №1 in LoL S10

Continuous damage increase

Plus more mana and threat to enemies

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Karthus runes: mid №2 in LoL S10

Continuous damage increase

Plus maximum increase in strength

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Sorcery
  7. Transcendence
  8. Gathering Storm
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Sorcery. Transcendence is perfect for champions who need to reduce cooldowns. Gathering Storm will allow you to take up the enemy... read more

Karthus runes: mid №3 in LoL S10

Continuous damage increase

Plus saving in the early game and CDR

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Inspiration
  7. Magical Footwear
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Cosmic Insight allows you to get... read more

Karthus runes: mid №4 in LoL S10

Abilities and attacks damage

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Summon Aery
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Summon Aery together with all the additional runes from Sorcery path will make Karthus much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Karthus runes: mid №5 in LoL S10

Harassing enemy with skills

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Arcane Comet
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Arcane Comet together with all the additional runes from Sorcery path will make Karthus much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more


Karthus runes for adc in League of Legends

All the optimal builds for bot lane in LoL

Karthus runes: adc №1 in LoL S10

Continuous damage increase

Plus more mana and threat to enemies

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Karthus runes: adc №2 in LoL S10

Continuous damage increase

Plus maximum increase in strength

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Sorcery
  7. Transcendence
  8. Gathering Storm
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Sorcery. Transcendence is perfect for champions who need to reduce cooldowns. Gathering Storm will allow you to take up the enemy... read more

Karthus runes: adc №3 in LoL S10

Continuous damage increase

Plus saving in the early game and CDR

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Inspiration
  7. Magical Footwear
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Inspiration. Magical Footwear are a good source of cost savings, and even give a little more speed. Cosmic Insight allows you to get... read more

Karthus runes: adc №4 in LoL S10

Abilities and attacks damage

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Summon Aery
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Summon Aery together with all the additional runes from Sorcery path will make Karthus much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Karthus runes: adc №5 in LoL S10

Harassing enemy with skills

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Arcane Comet
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Arcane Comet together with all the additional runes from Sorcery path will make Karthus much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more


Karthus runes for ARAM in League of Legends

All the optimal builds for the ARAM in LoL

Karthus runes: ARAM №1 in LoL S10

Continuous damage increase

Plus more mana and threat to enemies

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ultimate Hunter
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Karthus runes: ARAM №2 in LoL S10

Continuous damage increase

Plus maximum increase in strength

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ultimate Hunter
  6. Sorcery
  7. Transcendence
  8. Gathering Storm
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Sorcery. Transcendence is perfect for champions who need to reduce cooldowns. Gathering Storm will allow you to take up the enemy... read more

Karthus runes: ARAM №3 in LoL S10

Continuous damage increase

Plus getting a free stopwatch and CDR

Read complete description

  1. Domination
  2. Dark Harvest
  3. Cheap Shot
  4. Eyeball Collection
  5. Ultimate Hunter
  6. Inspiration
  7. Perfect Timing
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Dark Harvest together with all the additional runes from Domination path will make Karthus much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Inspiration. Perfect Timing is indispensable for champions who need stasis to play combinations, as well as for everyone buying... read more

Karthus runes: ARAM №4 in LoL S10

Harassing enemy with skills

Plus significant CDR of the ultimate

Read complete description

  1. Sorcery
  2. Arcane Comet
  3. Manaflow Band
  4. Transcendence
  5. Gathering Storm
  6. Domination
  7. Taste of Blood
  8. Ultimate Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Arcane Comet together with all the additional runes from Sorcery path will make Karthus much stronger while playing the ARAM in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ultimate Hunter will allow you to use the... read more