We present you all the best options available in S10. The runes listed below on the page showed effectiveness for this character in 2020 year, because they can unlock most of his strengths and also neutralize the maximum possible amount of weaknesses.
The list includes all the options that have any value nowadays. This will allow to flexibly adapt to your opponent in the role and team compositions in general when playing the champion Karma (for example, if you need to be really aggressive).
All the optimal builds for support in LoL
Plus resource recovery and CDR
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
Plus more survivability the whole game
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Resolve
Bone Plating
Revitalize
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Resolve. Bone Plating will reduce the incoming damage of the first enemy attacks and skills, which will make you less vulnerable... read more
Plus significant CDR of the ultimate
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Domination
Taste of Blood
Ultimate Hunter
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ultimate Hunter will allow you to use the... read more
Plus more mana and threat to enemies
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Precision
Presence of Mind
Coup de Grace
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more
Plus resource recovery and CDR
Primary path
Sorcery
Summon Aery
Manaflow Band
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionSummon Aery together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
Plus more survivability the whole game
Primary path
Sorcery
Summon Aery
Manaflow Band
Secondary
Resolve
Bone Plating
Revitalize
+ 2 others and statistics slots
Read complete descriptionSummon Aery together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Resolve. Bone Plating will reduce the incoming damage of the first enemy attacks and skills, which will make you less vulnerable... read more
Plus significant CDR of the ultimate
Primary path
Sorcery
Summon Aery
Manaflow Band
Secondary
Domination
Taste of Blood
Ultimate Hunter
+ 2 others and statistics slots
Read complete descriptionSummon Aery together with all the additional runes from Sorcery path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ultimate Hunter will allow you to use the... read more
Plus resource recovery and CDR
Primary path
Resolve
Guardian
Font of Life
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionGuardian together with all the additional runes from Resolve path will make Karma much stronger while playing support in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
All the optimal builds for mid lane in LoL
Plus resource recovery and CDR
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing mid lane in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
Plus significant CDR of the ultimate
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Domination
Taste of Blood
Ultimate Hunter
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing mid lane in season 10 League of Legends.
The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ultimate Hunter will allow you to use the... read more
Plus resource recovery and CDR
Primary path
Sorcery
Summon Aery
Manaflow Band
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionSummon Aery together with all the additional runes from Sorcery path will make Karma much stronger while playing mid lane in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
Plus additional increase of the CDR
Primary path
Inspiration
Unsealed Spellbook
Magical Footwear
Secondary
Sorcery
Nimbus Cloak
Transcendence
+ 2 others and statistics slots
Read complete descriptionUnsealed Spellbook together with all the additional runes from Inspiration path will make Karma much stronger while playing mid lane in season 10 League of Legends.
The secondary path is Sorcery. Nimbus Cloak will give the champion a good movement speed boost after using a summoner spell. Transcendence is perfect... read more
All the optimal builds for top lane in LoL
Plus more mana and increased CDR
Primary path
Resolve
Grasp of the Undying
Shield Bash
Secondary
Sorcery
Manaflow Band
Transcendence
+ 2 others and statistics slots
Read complete descriptionGrasp of the Undying together with all the additional runes from Resolve path will make Karma much stronger while playing top lane in season 10 League of Legends.
The secondary path is Sorcery. Manaflow Band will allow you to experience less problems with this resource through an increase in its amount and... read more
Plus resource recovery and CDR
Primary path
Resolve
Grasp of the Undying
Shield Bash
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionGrasp of the Undying together with all the additional runes from Resolve path will make Karma much stronger while playing top lane in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
Plus resource recovery and CDR
Primary path
Sorcery
Summon Aery
Manaflow Band
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionSummon Aery together with all the additional runes from Sorcery path will make Karma much stronger while playing top lane in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
Plus resource recovery and CDR
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Inspiration
Biscuit Delivery
Cosmic Insight
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing top lane in season 10 League of Legends.
The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more
All the optimal builds for the ARAM in LoL
Plus more mana and threat to enemies
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Precision
Presence of Mind
Coup de Grace
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing the ARAM in season 10 League of Legends.
The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more
Plus true damage and CDR of ultimate
Primary path
Sorcery
Arcane Comet
Manaflow Band
Secondary
Domination
Cheap Shot
Ultimate Hunter
+ 2 others and statistics slots
Read complete descriptionArcane Comet together with all the additional runes from Sorcery path will make Karma much stronger while playing the ARAM in season 10 League of Legends.
The secondary path is Domination. Cheap Shot will serve as a constant source of additional damage to enemies after applying any control to them. Ultimate... read more
Plus more mana and threat to enemies
Primary path
Domination
Dark Harvest
Cheap Shot
Secondary
Precision
Presence of Mind
Coup de Grace
+ 2 others and statistics slots
Read complete descriptionDark Harvest together with all the additional runes from Domination path will make Karma much stronger while playing the ARAM in season 10 League of Legends.
The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more
Plus more mana and threat to enemies
Primary path
Sorcery
Summon Aery
Manaflow Band
Secondary
Precision
Presence of Mind
Coup de Grace
+ 2 others and statistics slots
Read complete descriptionSummon Aery together with all the additional runes from Sorcery path will make Karma much stronger while playing the ARAM in season 10 League of Legends.
The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more