The complete list:

Mid lane (view best option)

Bot lane (view best option)

Top lane (view best option)

Runes for Cassiopeia in League of Legends season 10

We present you all the best options available in S10. The runes listed below on the page showed effectiveness for this character in 2020 year, because they can unlock most of his strengths and also neutralize the maximum possible amount of weaknesses.

The list includes all the options that have any value nowadays. This will allow to flexibly adapt to your opponent in the role and team compositions in general when playing the champion Cassiopeia (for example, if you need to be really aggressive).

Please, choose the position you need

Mid lane

Bot lane

Top lane


Cassiopeia runes for mid in League of Legends

All the optimal builds for mid lane in LoL

Cassiopeia runes: mid №1 in LoL S10

Damage and lots of healing

Plus restoration of health in the fight

Read complete description

  1. Precision
  2. Conqueror
  3. Presence of Mind
  4. Legend: Tenacity
  5. Coup de Grace
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Conqueror together with all the additional runes from Precision path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: mid №2 in LoL S10

Damage and lots of healing

Plus more mana and increased CDR

Read complete description

  1. Precision
  2. Conqueror
  3. Presence of Mind
  4. Legend: Tenacity
  5. Coup de Grace
  6. Sorcery
  7. Manaflow Band
  8. Transcendence
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Conqueror together with all the additional runes from Precision path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Sorcery. Manaflow Band will allow you to experience less problems with this resource through an increase in its amount and... read more

Cassiopeia runes: mid №3 in LoL S10

Impressive amount of mobility

Plus restoration of health in the fight

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: mid №4 in LoL S10

Impressive amount of mobility

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Cassiopeia runes: mid №5 in LoL S10

Impressive amount of mobility

Plus resource recovery and CDR

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Inspiration
  7. Biscuit Delivery
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more

Cassiopeia runes: mid №6 in LoL S10

Harassing enemy with skills

Plus restoration of health in the fight

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  1. Sorcery
  2. Arcane Comet
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Arcane Comet together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: mid №7 in LoL S10

The maximum burst damage

Plus more mana and threat to enemies

Read complete description

  1. Domination
  2. Electrocute
  3. Taste of Blood
  4. Eyeball Collection
  5. Ravenous Hunter
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 8 magic resistance

Electrocute together with all the additional runes from Domination path will make Cassiopeia much stronger while playing mid lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more


Cassiopeia runes for adc in League of Legends

All the optimal builds for bot lane in LoL

Cassiopeia runes: adc №1 in LoL S10

Damage and lots of healing

Plus restoration of health in the fight

Read complete description

  1. Precision
  2. Conqueror
  3. Presence of Mind
  4. Legend: Tenacity
  5. Coup de Grace
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Conqueror together with all the additional runes from Precision path will make Cassiopeia much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: adc №2 in LoL S10

Damage and lots of healing

Plus more mana and increased CDR

Read complete description

  1. Precision
  2. Conqueror
  3. Presence of Mind
  4. Legend: Tenacity
  5. Coup de Grace
  6. Sorcery
  7. Manaflow Band
  8. Transcendence
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Conqueror together with all the additional runes from Precision path will make Cassiopeia much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Sorcery. Manaflow Band will allow you to experience less problems with this resource through an increase in its amount and... read more

Cassiopeia runes: adc №3 in LoL S10

Impressive amount of mobility

Plus restoration of health in the fight

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: adc №4 in LoL S10

Impressive amount of mobility

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Cassiopeia runes: adc №5 in LoL S10

Impressive amount of mobility

Plus resource recovery and CDR

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Inspiration
  7. Biscuit Delivery
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing bot lane in season 10 League of Legends.

The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more


Cassiopeia runes for top in League of Legends

All the optimal builds for top lane in LoL

Cassiopeia runes: top №1 in LoL S10

Damage and lots of healing

Plus restoration of health in the fight

Read complete description

  1. Precision
  2. Conqueror
  3. Presence of Mind
  4. Legend: Tenacity
  5. Coup de Grace
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Conqueror together with all the additional runes from Precision path will make Cassiopeia much stronger while playing top lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: top №2 in LoL S10

Damage and lots of healing

Plus more mana and increased CDR

Read complete description

  1. Precision
  2. Conqueror
  3. Presence of Mind
  4. Legend: Tenacity
  5. Coup de Grace
  6. Sorcery
  7. Manaflow Band
  8. Transcendence
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Conqueror together with all the additional runes from Precision path will make Cassiopeia much stronger while playing top lane in season 10 League of Legends.

The secondary path is Sorcery. Manaflow Band will allow you to experience less problems with this resource through an increase in its amount and... read more

Cassiopeia runes: top №3 in LoL S10

Impressive amount of mobility

Plus restoration of health in the fight

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Domination
  7. Taste of Blood
  8. Ravenous Hunter
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing top lane in season 10 League of Legends.

The secondary path is Domination. Taste of Blood is a great way to maintain a high amount of health on the lane. Ravenous Hunter is an excellent source of... read more

Cassiopeia runes: top №4 in LoL S10

Impressive amount of mobility

Plus more mana and threat to enemies

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Precision
  7. Presence of Mind
  8. Coup de Grace
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing top lane in season 10 League of Legends.

The secondary path is Precision. Presence of Mind will restore part of the mana or energy when participating in the killing of the champion, as well as... read more

Cassiopeia runes: top №5 in LoL S10

Impressive amount of mobility

Plus resource recovery and CDR

Read complete description

  1. Sorcery
  2. Phase Rush
  3. Manaflow Band
  4. Transcendence
  5. Scorch
  6. Inspiration
  7. Biscuit Delivery
  8. Cosmic Insight
  9. 9 adaptive force
  10. 9 adaptive force
  11. 6 armor

Phase Rush together with all the additional runes from Sorcery path will make Cassiopeia much stronger while playing top lane in season 10 League of Legends.

The secondary path is Inspiration. Biscuit Delivery will provide health and mana on the lane, as well as increase the maximum amount of the latter. Cosmic... read more